UPSC Mains 2018 Medical Science Optional Paper I questions

43 questions from the Civil Services (Main) Examination 2018. Official UPSC paper (PDF) · All Medical Science Optional PYQs

1. Discuss the Functional components, Nucleus, course and distribution of 4th cranial nerve. Add a note on its clinical significance.

   10 marks

2. What are extra pyramidal tracts? Describe their functions. How do they differ from pyramidal tracts?

   10 marks

3. What is the regulatory mechanism of iron absorption at the level of intestine? What is the role of TIBC in iron metabolism? How does the body conserve iron?

4. Classify Arches of foot, Write in details about medial longitudinal Arch.

   10 marks

5. Give an account of characteristics of a hormone. Describe the hormonal regulation of calcium level in the blood.

   10 marks

6. Describe Hip Joint under the following headings: 20 Articular surface and Types

7. Blood supply and Nerve supply

8. Explain regulation of megakaryocytopoiesis.

   5 marks

9. Define the term "cardiac reserve". Explain how is its control governed?

   10 marks

10. Describe briefly

11. Role of PCR (Polymerase Chain Reaction) in the diagnosis and management of Mycobacterium tuberculosis.

12. Flat #? Role of iodine in synthesis and function of thyroid hormone, What is Graves Disease?

    5 marks

13. Explain the changes which takes place during luteal phase of menstrual cycle.

    10 marks

14. What are modes of contraction in a skeletal muscle? Give suitable examples. Explain length-tension relationship in skeletal muscle.

    10 marks

15. Describe the principle of Radio Immuno Assay (RIA). What are the main advantages and disadvantages of RIA technique.

    8 marks

16. What is folate trap? What are the methods of assessment of vitamin B), deficiency,

17. Describe the External, Internal features, parts of cerebellum. Add a note on the

18. Describe the structure of tRNA in detail, What is the energetics of synthesis of one peptide bond? What are the mhibitors of protein synthesis?

19. Give an account of monophylactic theory of haemopoiesis.

    8 marks

20. List growth promoting hormones. Explain their contribution to growth after birth.

21. Write down the Development of placenta, discuss the functions and anomalies of it.

22. Describe the Coronary Arteries. Add a note on cardiac dominance.

    8 marks

23. Define impaired glucose tolerance. Discuss the pathogenesis of Typel diabetes mellitus.

24. Discuss the strategic plans laid down by NACO for diagnosis of individuals with AIDS indicative disease symptoms.

    5 marks

25. Discuss the adverse effects associated with the use of antimicrobial agents.

    10 marks

26. Describe risk factors identified for breast carcinoma.

    5 marks

27. Discuss molecular subtypes of invasive breast carcinoma.

    5 marks

28. Define 'Head Injury', What ts the mechanism of 'Coup' and "Contre Coup' brain damage.

29. Discuss briefly the formula used for calculating the "Total Body Surface Area' involved in burns in an adult and a child.

    5 marks

30. Define nephrotic syndrome and enumerate its components. Discuss pathogenesis, histopathological, electron microscopic and immunofluorescence findings of

31. Describe the pathogenesis of granulomatous immune response in tuberculosis. Discuss gross and histomorphological features of central nervous system (CNS) tuberculosis.

    10 marks

32. What are different classes of drugs used in the treatment of hypertension? Discuss the mechanism of action, clinical uses and adverse effects of Sodium nitro

33. Write the laboratory diagnosis and complication of Plasmodium falciparum infection.

34. Enumerate species of Aspergillus, infections caused and laboratory diagnosis of

35. Define 'Rape' as per Criminal Law Amendment Act, 2013. An 11 yr old girl is brought to casualty with alleged history of rape 2 hours ago. Discuss the medico-legal examination in detail, including the samples that are to be collected.

36. Write a short note on the management of a case of aluminium phosphide poisoning.

37. Enumerate 6 major Blood Groups. Give the Mendel's laws of inheritance of the blood groups and their role in disputed paternity testing.

38. Aspirin should not be administered concurrently with warfarin

    5 marks

39. Patients chronically administered morphine remain constipated.

    5 marks

40. Discuss the epidemiology, pathogenesis and laboratory diagnosis of a patient presenting with bacillary dysentery.

41. Write short note on

42. Interferons and their uses arm & cart ere 4 nite sepals sei at quit are wes ware are aagT Define metastasis. What are the different pathways for the spread of cancer? Draw a flowchart describing the sequential steps involved in the hematogenous spread of a tumor. pathological features of CML-chronic phase.

    5 marks

43. Discuss precisely the mechanism of action, clinical uses and side effects of the following ¢

    10 marks