In the context of hereditary diseases, consider the following statements : 1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg. 2. A child inherits mitochondrial diseases entirely from mother and not from father. Which of the statements given above is/are correct?

Question

In the context of hereditary diseases, consider the following statements : ​ 1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg. ​ 2. A child inherits mitochondrial diseases entirely from mother and not from father. ​ Which of the statements given above is/are correct? ​

CollectorBabu · Accepted Answer

Correct Answer: 1 only ​. Statement 1 is correct: Mitochondrial dysfunction is implicated in disease and in age-related infertility. Mitochondrial replacement therapies (MRT) in oocytes or zygotes such as pronuclear (PNT), spindle (ST) or polar body (PBT) transfer could prevent second generation transmission of mitochondrial DNA (mtDNA) defects. It can be done before and after in vitro fertilization. Statement 2 is incorrect:   Extreme statement, in rare cases can be inherited from fathers as well. However, it is mostly inherited from the mother.

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